Domperidone | for nausea and vomiting - Gafacom (For health. For knowledge)

Domperidone | for nausea and vomiting

Domperidone Tablets contain domperidone as the active ingredient, which belongs to a group of medicines called 'dopamine antagonists'. This medicine is used to treat nausea (feeling sick) and vomiting (being sick) in adults and adolescents (12 years of age and older and weighing 35 kg or more).
Domperidone is a dopamine antagonist (blocking both D1 and D2 receptors)

Mechanism of Action


Domperidone is a dopamine antagonist (blocking both D1 and D2 receptors) Dopamine antagonism stimulates gastric emptying, increased rate of intestinal transit time and enhanced strength of oesophageal sphincter contractions.
The antiemetic effect of domperidone is due to the prokinetic effect on the gastrointestinal tract combined with antagonisation of dopamine receptors in the chemo trigger zone (CTZ).
Domperidone does not readily cross the blood brain barrier.

Warnings and precautions

Before taking this medicine contact your doctor if you:
• suffer from liver problems (liver function impairment or failure)
• suffer from kidney problems (kidney function impairment or failure). It is advisable to ask your doctor for advice in case of prolonged treatment as you may need to take a lower dose or take this medicine less often, and your doctor may want to examine you regularly.

Domperidone may be associated with an increased risk of heart rhythm disorder and cardiac arrest. This risk may be more likely in those over 60 years old or taking doses higher than 30mg per day. The risk also increases when domperidone is given together with some drugs.



Tell your doctor or pharmacist if you are taking drugs to treat infection (fungal infections or bacterial infection) and/or if you have heart problems or AIDS/HIV. 

Domperidone should be used at the lowest effective dose. While taking domperidone, contact your doctor if you experience heart rhythm disorders such as palpitations, trouble breathing, and loss of consciousness. Treatment with domperidone should be stopped.

Contraindications

Known hypersensitivity to domperidone
Known hepatic disease
Use with caution in patients with a history of cardiac problems (QTc prolongation) liver impairment or gastrointestinal obstruction.
The film coated tablets contain lactose and may not be suitable to be taken by patients with lactose intolerance.

Interactions

Antacid medications (eg. Mylanta, omeprazole ranitidine etc) may decrease the absorption of domperidone.
Medications which inhibit CYP3A4 may increase domperidone concentrations include; fluconazole, itraconazole, ketoconazole, voriconazole, clarithromycin, erythromycin, diltiazem, verapamil, amiodarone.
Risk of QTc prolongation may be increased if domperidone is taken in combination with other medications that are known to prolong QTc interval eg. Fluconazole, ketoconazole, voriconazole, erythromycin, amiodarone.

Taking Domperidone Tablets with food and drink
The tablets should be taken before meals.

Driving and using machines
You may feel sleepy, confused or have less control over your movements while taking Domperidone tablets. If this happens, do not drive or use any tools or machines

Dosage and administration

Always take Domperidone Tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.  For oral use only. The tablets must be swallowed with a glass of water.
Take the tablets 15 to 30 minutes before meals and, if needed, before you go to bed. Do not crush or chew them.

Duration of treatment:

Symptoms usually resolve with 3-4 days of taking this medicine. Do not take Domperidone tablets for longer than 7 days without consulting your doctor.
Adults and adolescents 12 years of age and older with a body weight of 35 kg or more
The usual dose is one tablet taken up to three times per day, if possible before meals.
Do not take more than three tablets per day.




Reference
https://www.medicines.org.uk/emc/product/556/smpc
https://www.medicinenet.com/domperidone-oral/article.htm
https://www.mayoclinic.org/drugs-supplements/domperidone-oral-route/side-effects/drg-20063481?p=1
https://www.nhs.uk/medicines/domperidone/
https://www.medicinesforchildren.org.uk/domperidone-gastro-oesophageal-reflux
https://patient.info/medicine/domperidone-for-sickness-motilium
https://chealth.canoe.com/drug/getdrug/dom-domperidone
https://www.drugbank.ca/drugs/DB01184
Domperidone | for nausea and vomiting Domperidone | for nausea and vomiting Reviewed by gafacom on June 26, 2020 Rating: 5

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