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Ertapenem | an antibiotic of the beta-lactam group


Ertapenem is an antibiotic of the beta-lactam group. It has the ability to kill a wide range of bacteria (germs) that cause infections in various parts of the body.
Antibiotic Class: Carbapenem

It has the ability to kill a wide range of bacteria (germs) that cause infections

Antimicrobial Spectrum:



Aerobic gram-positive microorganisms: S. aureus (methicillin susceptible strains only), S.pyogenes, S. agalactiae; Aerobic gram-negative microorganisms: E. coli, H. influenzae, M. catarrhalis, K. pneumonia; anaerobic microorganisms: Bacteroides fragilis and other Bacteroides species, C.clostridioforme, Peptostreptococcus species

Indications:

Treatment of the following moderate-to-severe infections: Complicated intra-abdominal infections, complicated skin and skin structure infections (including diabetic foot infections without osteomyelitis, animal and human bites), complicated UTI (including pyelonephritis), acute pelvic infections (including postpartum endomyometritis, septic abortion, postsurgical gynecologic infections), and community-acquired pneumonia. Prophylaxis of surgical site infection following elective colorectal surgery. Antibacterial coverage includes aerobic grampositive organisms, aerobic gram-negative organisms, and anaerobic organisms.

Dosage:

Sterile lyophilized 1 g powder for intravenous infusion or for intramuscular injection
Acute pelvic infection: 1 g IV/IM daily for 3-10 days
Community-acquired pneumonia: 1 g IV/IM daily for 10-14 days
Intra-abdominal infections: 1 g IV/IM daily for 5-14 days
Skin/skin structure infections: 1 g IV/IM daily for 7-14 days
Urinary tract infection: 1 g IV/IM daily for 10-14 days

Adverse Effects:

Gastrointestinal: Nausea, diarrhea, abdominal pain, vomiting, constipation, GERD
Cardiovascular System: Edema, chest pain, tachycardia
Central Nervous System: Headache, altered mental status (confusion, disorientation, somnolence), seizures
Hematologic: Decreases in hemoglobin and hematocrit, decrease in platelet counts, eosinophilia
Genitourinary: Vaginitis
Renal: Renal insufficiency
Hepatic: Increased serum transaminases and alkaline phosphatase
Respiratory: Dyspnea, cough, pharyngitis, and “respiratory distress”
Dermatologic: Erythrema, pruritis, rash; extravasation at injection site, phlebitis, thrombophlebitis

Contraindications/Warnings/Precautions:
Contraindications: Prior anaphylactic reactions to beta- lactams, hypersensitivity to amide-type anesthetics
Precautions: Known or suspected CNS disorders including seizure history (increased risk for seizures)

Drug Interactions:
Probenecid (moderate severity): Probenecid inhibits the renal excretion of ertapenem thereby increasing its plasma concentrations and prolonging its elimination half- life.

Pregnancy:
Category B: No evidence of risk in humans but studies inadequate.

Brand names/Manufacturer: Invanz/Merck in the following countries: Australia, United Kingdom, Singapore, New Zealand, Germany, Ireland, France, Austria, Sweden, Israel, Finland, and Belgium



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