Cefazolin for Injection USP| Antibiotic


Cefazolin for Injection USP and Dextrose Injection USP is a sterile, non-pyrogenic, single use, packaged combination of Cefazolin Sodium USP (lyophilized) and sterile iso-osmotic diluent in the sterile container. The Container is a flexible dual chamber container. After reconstitution the approximate osmolality for Cefazolin for Injection USP and Dextrose Injection USP is 290 mOsmol/kg.

Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis

The drug chamber is filled with sterile lyophilized Cefazolin Sodium USP, a semisynthetic cephalosporin and has the following IUPAC nomenclature: Sodium (6R,-7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.
Antibiotic Class: First-Generation Cephalosporin



Antimicrobial Spectrum:

Gram-positive bacteria: methicillin-susceptible Staphylococcus aureus (MSSA), coagulase –negative Staphylococci, penicillin-susceptible Streptococcus pneumoniae, Streptococci spp.
Gram-negative bacteria: Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis

Mechanism of Action:

Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis through inactivation of one or more penicillin-binding proteins and inhibiting cross-linking of the peptidoglycan structure. The cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.

Indications:

Treatment of respiratory tract, skin, genital, urinary tract, biliary tract, bone and joint infections, and septicemia due to susceptible gram-positive cocci (exceptEnterococcus); some gram-negative bacilli including E. coli, Proteus, and Klebsiella may be susceptible; surgical prophylaxis

Adverse Reactions:

Hematologic: Neutropenia, leukopenia, eosinophilia, thrombocytopenia, thrombocytosis, impaired platelet aggregation
Dermatologic: Rash (maculopapular), puritis, urticaria
Gastrointestinal: Diarrhea
Hepatic: Abnormal liver function tests
Renal: Interstitial nephitis
Other: Anaphylaxis

Dosage:

IV/IM: 500mg/10ml injection
1gram powder for reconstitution (IM)
Adult dose: 1-2g IV/IM q8h
Mild infections: 250-500 mg IV/IM q8h
Moderate to severe infections: 0.5-1 g IV/IM q6-8h
Severe, life-threatening infections: 1-1.5 g IV/IM q6h
Perinatal GBS disease, intrapartum prophylaxis: 2 g IV x 1 dose (started at time of labor or rupture of membranes) then 1 g IV q8h until delivery
Pre-operative use: 1 g IV/IM 0.5-1 hr prior to surgery, then 0.5-1 g IV/IM q6-8h x 24 hr

Contraindications/Warnings/Precautions:

Drug Interactions:
Live Typhoid Vaccine - decreased immunological response to the typhoid vaccine
Pregnancy Risk Factor: B

Brand names/Manufacturer:
ACEF (SmithKline Beecham – USA, CANADA,) · AREUZOLIN (Areu - SPAIN) · BAKTOZIL (Chephasaar - GERMANY) · BASOCEF (DeltaSelect - GERMANY) · BIAZOLINA (Fermenti - ITALY) · BIOZOLIN (Novartis - GREECE) · BOR-CEFAZOL (Proter - ITALY) · BRIZOLINA (Bristol-Myers Squibb - SPAIN) · CAMIL (Martin - SPAIN) · CARICEF (Antibioticos - SPAIN) · CEFABIOZIM (IPA - ITALY) · CEFACENE (Centrum -SPAIN) · CEFACIDAL (Bristol-Myers Squibb – FRANCE, NETHERLANDS, BELGIUM, SOUTH AFRICA, MEXICO, TAHILAND) · CEFADREX (Vir - SPAIN) · CEFAKES (Inexfa - SPAIN) · CEFALIN (Atlantic - THAILAND) · CEFAMEZIN (Pharmacia . – ITALY, JAPAN, HONG KONG, ISRAEL, THAILAND) · CEFAMEZIN (Knoll – SPAIN, PORTUGAL, BRAZIL, AUSTRALIA) · CEFAMUSEL (Cruz - SPAIN) · CEFA RESAN (Alacan - SPAIN) · CEFAZIL (Italfarmaco - ITALY) · CEFAZILLIN (TP- THAILAND) · CEFAZINA (Chemil - ITALY) · CEFAZOL (General Drugs - THAILAND) · CEFAZOLIN (various generic manufacturers -USA, CANADA))
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Cefazolin for Injection USP| Antibiotic Cefazolin for Injection USP| Antibiotic Reviewed by gafacom on May 12, 2020 Rating: 5

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