Note to readers

We have started a forum hosted by Nabble, this forum can be accessed directly on our blog. The purpose of starting a forum is to help viewers and readers with questions to have a platform of sharing them and provide answers.


We are determined to be your source for health and medical information, you can help us by engaging in the forum

Cefazolin for Injection USP| Antibiotic


Cefazolin for Injection USP and Dextrose Injection USP is a sterile, non-pyrogenic, single use, packaged combination of Cefazolin Sodium USP (lyophilized) and sterile iso-osmotic diluent in the sterile container. The Container is a flexible dual chamber container. After reconstitution the approximate osmolality for Cefazolin for Injection USP and Dextrose Injection USP is 290 mOsmol/kg.

Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis

The drug chamber is filled with sterile lyophilized Cefazolin Sodium USP, a semisynthetic cephalosporin and has the following IUPAC nomenclature: Sodium (6R,-7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.
Antibiotic Class: First-Generation Cephalosporin



Antimicrobial Spectrum:

Gram-positive bacteria: methicillin-susceptible Staphylococcus aureus (MSSA), coagulase –negative Staphylococci, penicillin-susceptible Streptococcus pneumoniae, Streptococci spp.
Gram-negative bacteria: Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis

Mechanism of Action:

Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis through inactivation of one or more penicillin-binding proteins and inhibiting cross-linking of the peptidoglycan structure. The cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.

Indications:

Treatment of respiratory tract, skin, genital, urinary tract, biliary tract, bone and joint infections, and septicemia due to susceptible gram-positive cocci (exceptEnterococcus); some gram-negative bacilli including E. coli, Proteus, and Klebsiella may be susceptible; surgical prophylaxis

Adverse Reactions:

Hematologic: Neutropenia, leukopenia, eosinophilia, thrombocytopenia, thrombocytosis, impaired platelet aggregation
Dermatologic: Rash (maculopapular), puritis, urticaria
Gastrointestinal: Diarrhea
Hepatic: Abnormal liver function tests
Renal: Interstitial nephitis
Other: Anaphylaxis

Dosage:

IV/IM: 500mg/10ml injection
1gram powder for reconstitution (IM)
Adult dose: 1-2g IV/IM q8h
Mild infections: 250-500 mg IV/IM q8h
Moderate to severe infections: 0.5-1 g IV/IM q6-8h
Severe, life-threatening infections: 1-1.5 g IV/IM q6h
Perinatal GBS disease, intrapartum prophylaxis: 2 g IV x 1 dose (started at time of labor or rupture of membranes) then 1 g IV q8h until delivery
Pre-operative use: 1 g IV/IM 0.5-1 hr prior to surgery, then 0.5-1 g IV/IM q6-8h x 24 hr

Contraindications/Warnings/Precautions:

Drug Interactions:
Live Typhoid Vaccine - decreased immunological response to the typhoid vaccine
Pregnancy Risk Factor: B

Brand names/Manufacturer:
ACEF (SmithKline Beecham – USA, CANADA,) · AREUZOLIN (Areu - SPAIN) · BAKTOZIL (Chephasaar - GERMANY) · BASOCEF (DeltaSelect - GERMANY) · BIAZOLINA (Fermenti - ITALY) · BIOZOLIN (Novartis - GREECE) · BOR-CEFAZOL (Proter - ITALY) · BRIZOLINA (Bristol-Myers Squibb - SPAIN) · CAMIL (Martin - SPAIN) · CARICEF (Antibioticos - SPAIN) · CEFABIOZIM (IPA - ITALY) · CEFACENE (Centrum -SPAIN) · CEFACIDAL (Bristol-Myers Squibb – FRANCE, NETHERLANDS, BELGIUM, SOUTH AFRICA, MEXICO, TAHILAND) · CEFADREX (Vir - SPAIN) · CEFAKES (Inexfa - SPAIN) · CEFALIN (Atlantic - THAILAND) · CEFAMEZIN (Pharmacia . – ITALY, JAPAN, HONG KONG, ISRAEL, THAILAND) · CEFAMEZIN (Knoll – SPAIN, PORTUGAL, BRAZIL, AUSTRALIA) · CEFAMUSEL (Cruz - SPAIN) · CEFA RESAN (Alacan - SPAIN) · CEFAZIL (Italfarmaco - ITALY) · CEFAZILLIN (TP- THAILAND) · CEFAZINA (Chemil - ITALY) · CEFAZOL (General Drugs - THAILAND) · CEFAZOLIN (various generic manufacturers -USA, CANADA))
·



Post a comment

0 Comments