Chitosan

Chitosan occurs as odorless, white or creamy-white powder or flakes

Chitosan occurs as odorless, white or creamy-white powder or flakes. Fiber formation is quite common during precipitation and the chitosan may look ‘cottonlike’

Nonproprietary Names
  • BP: Chitosan Hydrochloride
  • PhEur: Chitosan Hydrochloride
Synonyms
2-Amino-2-deoxy-(1, 4)-b-D-glucopyranan; chitosani hydrochloridum; deacetylated chitin; deacetylchitin; b-1,4-poly-D-glucosamine; poly-D-glucosamine; poly-(1,4-b-D-glucopyranosamine).




Chemical Name and CAS Registry Number
Poly-b-(1, 4)-2-Amino-2-deoxy-D-glucose [9012-76-4]

Empirical Formula and Molecular Weight

Partial deacetylation of chitin results in the production of chitosan, which is a polysaccharide comprising copolymers of glucosamine and N-acetylglucosamine. Chitosan is the term applied to deacetylated chitins in various stages of deacetylation and depolymerization and it is therefore not easily defined in terms of its exact chemical composition. 

A clear nomenclature with respect to the different degrees of N-deacetylation between chitin and chitosan has not been defined, and as such chitosan is not one chemical entity but varies in composition depending on the manufacturer.

In essence, chitosan is chitin sufficiently deacetylated to form soluble amine salts. The degree of deacetylation necessary to obtain a soluble product must be greater than 80–85%. Chitosan is commercially available in several types and grades that vary in molecular weight by 
10,000 –1, 000,000, and vary in degree of deacetylation and viscosity.

Functional Category
Coating agent; disintegrant; film-forming agent; mucoadhesive; tablet binder; viscosity increasing agent.

Applications in Pharmaceutical Formulation or Technology

Chitosan is used in cosmetics and is under investigation for use in a number of pharmaceutical formulations. The suitability and performance of chitosan as a component of pharmaceutical formulations for drug delivery applications has been investigated in numerous studies.These include controlled drug delivery applications, use as a component of mucoadhesive dosage forms, rapid release dosage forms, improved peptide delivery, colonic drug delivery systems, and use for gene delivery.

Chitosan has been processed into several pharmaceutical forms including gels, films, beads, microspheres, tablets, and coatings for liposomes. Furthermore, chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes.



Chitosan Chitosan Reviewed by gafacom on April 01, 2020 Rating: 5

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