Butylene Glycol

Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste.

Butane-1,3-diol; 1,3-butylene glycol; b-butylene glycol
Butane-1,3-diol; 1,3-butylene glycol; b-butylene glycol; 1,3-dihydroxybutane; methyltrimethylene glycol.

Chemical Name and CAS Registry Number
1, 3-Butanediol [107-88-0]

Empirical Formula and Molecular Weight
C4H10O2 90.14

Functional Category

Antimicrobial preservative; humectant; solvent; water-miscible cosolvent.

Applications in Pharmaceutical Formulation or Technology

Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances. In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at 8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.

Method of Manufacture

Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

Related Substances

Propylene glycol

Butylene Glycol Butylene Glycol Reviewed by gafacom on April 01, 2020 Rating: 5

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