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Butylene Glycol

Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste.

Butane-1,3-diol; 1,3-butylene glycol; b-butylene glycol
Butane-1,3-diol; 1,3-butylene glycol; b-butylene glycol; 1,3-dihydroxybutane; methyltrimethylene glycol.

Chemical Name and CAS Registry Number
1, 3-Butanediol [107-88-0]

Empirical Formula and Molecular Weight
C4H10O2 90.14

Functional Category

Antimicrobial preservative; humectant; solvent; water-miscible cosolvent.

Applications in Pharmaceutical Formulation or Technology

Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances. In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at 8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.

Method of Manufacture

Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

Related Substances

Propylene glycol

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