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Bronopol

2-Bromo-2-nitro-1,3-propanediol

Bronopol is a white or almost white crystalline powder; odorless or with a faint characteristic odor.

Nonproprietary Names
  • BP: Bronopol
Synonyms




2-Bromo-2-nitro-1,3-propanediol; b-bromo-b-nitrotrimethyleneglycol; Myacide.

Chemical Name and CAS Registry Number
2-Bromo-2-nitropropane-1,3-diol [52-51-7]

Empirical Formula and Molecular Weight
C3H6BrNO4 200.00

Functional Category

Antimicrobial preservative; antiseptic.

Applications in Pharmaceutical Formulation or Technology

Bronopol 0.01–0.1% w/v is used as an antimicrobial preservative either alone or in combination with other preservatives in topical pharmaceutical formulations, cosmetics, and toiletries; the usual concentration is 0.02% w/v.

Method of Manufacture

Bronopol is synthesized by the reaction of nitromethane with paraformaldehyde in an alkaline environment, followed by bromination. After crystallization, bronopol powder may be milled to produce a powder of the required fineness.



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