Nicotinamide, Riboflavine, Thiamine Hydrochloride (Intaplex)

Pharmacological actions

Intaplex is a therapeutic class of Vitamin B complex supplement

Vitamin B1

Thiamine, a water-soluble vitamin, is an essential coenzyme for carbohydrate metabolism. Severe deficiency leads to the development of Beriberi (peripheral neuritis, muscle wasting and muscle weakness and paralysis).
The physiologically active form of thiamine, thiamine pyrophosphate (cocarboxylase), serves as a coenzyme of carboxylase and is involved in the decarboxylation of α-keto acids, such as pyruvic acid and α-detoglutaric acid
Intaplex is a therapeutic class of Vitamin B complex supplement


Riboflavin, a water-soluble vitamin, is essential for the utilization of energy from food. The active phosphorylated forms, flavine mononucleotide (FMN) and flavine adenine dinucleotide (FAD) are involved as coenzymes in oxidative/reductive metabolic reactions. It is also necessary for the functioning of pyridoxine and nicotinic acid. Deficiency leads to Riboflavinosis (cheilosis, angular stomatitis, glossitis, keratitis and seborrhaeic dermatitis)


Nicotinamide is a water-soluble vitamin B substance which is converted to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). These coenzymes are involved in electron transfer reactions in the respiratory chain.
Deficiency leads to Pellagra (skin lesions, hyperpigmentation and hyperkeratinisation, diarrhea, abdominal pain, glossitis, stomatitis, loss of appetite, headache, and lethargy, mental and neurological disturbances)


Vitamin B1
Thiamine is well absorbed from the gastro-intestinal tract following oral administration, although absorption of large doses is limited. It is widely distributed to most body tissues, and appears in breast milk. Thiamine is not stored to any appreciable extent in the urine as unchanged Thiamine or as metabolites.


Riboflavine is readily absorbed from the gastro-intestinal tract. Although riboflavin is widely distributed to body tissues little is stored in the body. It is converted in the body to the coenzyme flavine mononucleotide (FMN; riboflavin-5-phosphate) and then to another coenzyme flavine adenine dinucleotide (FAD). About 60% of FMN and FAD are bound to plasma proteins.
Riboflavin is excreted in the urine, partly as metabolites. As the dose increases, large amounts are excreted unchanged. Riboflavin crosses the placenta and is excreted in breast milk.


It is readily absorbed from the gastro-intestinal tract following oral administration and widely distributed in the body tissues. Nicotinic acid appears in breast milk. The main route of metabolism is their conversion to N-methylnicotinamide and the 2-pyridone and 4-pyridone derivatives; nicotinuric acid and nicotinamide are excreted unchanged in urine following therapeutic doses; however the amount excreted unchanged is increased with large doses

Dosage and administration: As directed by a doctor


Hypersensitivity to any of the ingredients, hypercalcaemia

Adverse effects and precautions

Adverse effects seldom occur following administration of thiamine but hypersensitivity reactions have occurred, mainly after parenteral administration. These reactions have ranged in severity from very mild to, very rarely, fatal anaphylactic shock.
Nicotinamide does not have a vasodilator action

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