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Calcium Lactate

Calcium lactate occurs as white or almost white, crystalline or granular powder. It is slightly efflorescent.

Nonproprietary Names

  • BP: Calcium Lactate Pentahydrate
  • JP: Calcium Lactate Hydrate
  • PhEur: Calcium Lactate Pentahydrate
  • USP: Calcium Lactate
Calcium Lactate Pentahydrate

Calcii lactas pentahydricus; calcium bis (2-hydroxypropanoate) pentahydrate; calcium dilactate; calcium lactate (1:2) hydrate; calcium lactate (1:2) pentahydrate; E327; 2-hydroxypropanoic acid, calcium salt; lactic acid, calcium salt; mixture of calcium (2R)-, (2S)- and (2RS)-2-hydroxypropanoates pentahydrates; propanoic acid, 2-hydroxy-, calcium salt (2:1), hydrate; Puracal.

Chemical Name and CAS Registry Number
  • Calcium lactate anhydrous        [814-80-2]
  • Calcium lactate monohydrate and trihydrate      [41372-22-9]
  • Calcium lactate pentahydrate    [5743-47-5] and     [63690-56-2]

Empirical Formula and Molecular Weight

  • C6H10CaO6 218.2 (anhydrous)
  • C6H10CaO6.H2O 236.0 (monohydrate)
  • C6H10CaO6.3H2O 272.3 (trihydrate)
  • C6H10CaO6.5H2O 308.3 (pentahydrate)

Functional Category

Antimicrobial preservative; buffering agent; crosslinking agent; tablet and capsule diluent; tablet binder; tablet filler; therapeutic agent; thickening agent.

Applications in Pharmaceutical Formulation or Technology

Calcium lactate is used as a bioavailability enhancer and nutrient supplement in pharmaceutical formulations. A spray-dried grade of calcium lactate pentahydrate has been used as a tablet diluent in direct compression systems, and has been shown to have good compactability. The properties of the pentahydrate form have been considered superior to those of calcium lactate trihydrate when used in direct compression tablet formulations.

Tablet properties may be affected by the hydration state of the calcium lactate and particle size of the material: reducing particle size increased crushing strength, whereas storage of tablets at elevated temperature resulted in dehydration accompanied by areduction in crushing strength. 

Calcium lactate has also been used as the source of calcium ions in the preparation of calcium alginate microspheres for controlled release delivery of active agents. It has been shown to result in lower calcium concentrations in the finished microspheres when compared with calcium acetate. Therapeutically, calcium lactate has been used in preparations for the treatment of calcium deficiency.

Method of Manufacture

Calcium lactate is prepared commercially by neutralization with calcium carbonate or calcium hydroxide of lactic acid obtained from fermentation of dextrose, molasses, starch, sugar, or whey.

Related Substances
Lactic acid; sodium lactate.

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