Benzethonium Chloride - Gafacom (For health. For knowledge)

Benzethonium Chloride

Benzethonium chloride occurs as a white crystalline

Benzethonium chloride occurs as a white crystalline material with a mild odor and very bitter taste.

Nonproprietary Names

BP: Benzethonium Chloride
JP: Benzethonium Chloride
PhEur: Benzethonium Chloride
USP: Benzethonium Chloride



Synonyms

Benzethonii chloridum; benzyldimethyl-[2-[2-(p-1,1,3,3-tetramethylbutylphenoxy) ethoxy]ethyl]ammonium chloride; BZT; diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride; Hyamine 1622.

Chemical Name and CAS Registry Number
N,N-Dimethyl-N-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy] ethoxy]ethyl]benzene-methanaminium chloride [121-54-0]

Empirical Formula and Molecular Weight
C27H42ClNO2 448.10

Functional Category: Antimicrobial preservative; antiseptic; disinfectant.

Applications in Pharmaceutical Formulation or Technology

Benzethonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative. Typically, it is used for this purpose in injections, ophthalmic and otic preparations at concentrations 0.01–0.02% w/v. Benzethonium chloride may also be used as a wetting and solubilizing agent, and as a topical disinfectant.
In cosmetics such as deodorants, benzethonium chloride may be used as an antimicrobial preservative in concentrations up to 0.5% w/v. The physical properties and applications of benzethonium chloride are similar to those of other cationic surfactants such as cetrimide.

Method of Manufacture

p-Diisobutylphenol is condensed in the presence of a basic catalyst with b,b0-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.

Related Substances
Benzalkonium chloride; cetrimide



Benzethonium Chloride Benzethonium Chloride Reviewed by gafacom on March 31, 2020 Rating: 5

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