Albumin

The USP 32 describes albumin human as a sterile nonpyrogenic preparation of serum albumin obtained from healthy human donors. It is available as a solution containing 4, 5, 20, or 25 g of serum albumin in 100mL of solution, with not less than 96% of the total protein content as albumin. The solution contains no added antimicrobial preservative but may contain sodium acetyltryptophanate with or without sodium caprylate as a stablizing agent.
Albumins derived from animal sources are also commercially available, e.g. bovine serum albumin.

The PhEur 6.0 similarly describes albumin solution as an aqueous solution of protein obtained from human plasma. It is available as a concentrated solution containing 150–250 g/L of total protein or as an isotonic solution containing 35–50 g/L of total protein. Not less than 95% of the total protein content is albumin. A suitable stabilizer against the effects of heat, such as sodium caprylate (sodium octanoate) or N-acetyltryptophan or a combination of these two at a suitable concentration, may be added, but no antimicrobial preservative is added.

Aqueous albumin solutions are slightly viscous and range in color from almost colorless to amber depending upon the protein concentration. In the solid state, albumin appears as brownish amorphous lumps, scales, or powder.

Related Substances
Albumins derived from animal sources are also commercially available, e.g. bovine serum albumin.



Nonproprietary Names
  • BP: Albumin Solution
  • PhEur: Human Albumin Solution
  • USP: Albumin Human

Synonyms
Alba; Albuconn; Albuminar; albumin human solution; albumin humani solutio; Albumisol; Albuspan; Albutein; Buminate; human serum albumin; normal human serum albumin; Octalbin; Plasbumin; plasma albumin; Pro-Bumin; Proserum; Zenalb.

Chemical Name and CAS Registry Number
Serum albumin [9048-49-1]

Empirical Formula and Molecular Weight




Human serum albumin has a molecular weight of about 66 500 and is a single polypeptide chain consisting of 585 amino acids. Characteristic features are a single tryptophan residue, a relatively low content of methionine (6 residues), and a large number of cysteine  and of charged amino acid residues of aspartic acid, glutamic acid, lysine , and arginine.

Functional Category
Stabilizing agent; therapeutic agent.

Reference
https://www.medicalnewstoday.com/articles/322403
https://account.allinahealth.org/library/content/1/3480
https://www.frontiersin.org/articles/10.3389/fphys.2014.00299/full
http://chemocare.com/chemotherapy/side-effects/hypoalbuminemia-low-albumin.aspx
https://www.mountsinai.org/health-library/tests/albumin-blood-serum-test
https://www.lhsc.on.ca/critical-care-trauma-centre/albumin-and-edema
http://www.rnceus.com/lf/lfalb.html
http://www.acb.org.uk/Nat%20Lab%20Med%20Hbk/Albumin.pdf
https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840080234
http://vetfolio-vetstreet.s3.amazonaws.com/mmah/77/432065c5a44ad1b009bba9adba7e4b/filePV_26_12_932.pdf
https://www.scielo.br/pdf/abcd/v23n2/05.pdf
https://www.amjmed.com/article/S0002-9343(17)30800-8/pdf
http://www.spectrum-diagnostics.com/data/Albumin.pdf
https://www.biotec-co.com/images/products/clinical_chemistry/kits/chemistry/Albumin.pdf
http://www.linear.es/ficheros/archivos/4_1101000I.pdf
http://www.kidney-international.org/article/S0085-2538(15)49851-5/pdf
http://www.tulipgroup.com/Coral_New2/html/pack_inserts/Albumin%20Kit.pdf

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