Acetone: A colorless volatile, flammable, transparent liquid


Acetone is a colorless volatile, flammable, transparent liquid, with a sweetish odor and pungent sweetish taste.

Nonproprietary Names
  • BP: Acetone
  • PhEur: Acetone
  • USP-NF: Acetone
Acetone is used as a solvent or cosolvent in topical preparations, and as an aid in wet granulation.

Synonyms

Acetonum; dimethylformaldehyde; dimethyl ketone; b-ketopropane; pyroacetic ether.

Chemical Name and CAS Registry Number
  • 2-Propanone [67-64-1]
Empirical Formula and Molecular Weight
  • C3H6O 58.08
Functional Category
  • Solvent.
Applications in Pharmaceutical Formulation or Technology

Acetone is used as a solvent or cosolvent in topical preparations, and as an aid in wet granulation. It has also been used when formulating tablets with water-sensitive active ingredients, or to solvate poorly water-soluble binders in a wet granulation process.

Acetone has also been used in the formulation of microspheres to enhance drug release. Owing to its low boiling point, acetone hasbeen used to extract thermolabile substances from crude drugs.

Typical Properties
  • Boiling point 56.28͒C
  • Flash point –208C
  • Melting point 94.38C
  • NIR spectra see Figure 1.
  • Refractive index n D20 = 1.359
  • Solubility Soluble in water; freely soluble in ethanol (95%).
  • Vapor pressure 185mmHg at 208C
Method of Manufacture

Acetone is obtained by fermentation as a by-product of n-butyl alcohol manufacture, or by chemical synthesis from isopropyl alcohol; from cumene as a by-product in phenol manufacture; or from propane as a by-product of oxidation-cracking.





References
https://en.wikipedia.org/wiki/Acetone
https://www.chemicalsafetyfacts.org/acetone/
https://pubchem.ncbi.nlm.nih.gov/compound/Acetone
https://www.webmd.com/diet/what-is-acetone
https://www.britannica.com/science/acetone
https://study.com/academy/lesson/what-is-acetone-structure-uses-formula.html
https://deq.mt.gov/Portals/112/Land/hazwaste/documents/acetone.pdf
https://www.labchem.com/tools/msds/msds/LC10420.pdf
http://sds.chemtel.net/webclients/safariland/finished_goods/Pioneer%20Forensics%20-%20PF003%20-%20Acetone.pdf
http://dkt.net.au/msdsfiles/acetone.pdf
Acetone: A colorless volatile, flammable, transparent liquid Acetone: A colorless volatile, flammable, transparent liquid Reviewed by gafacom on March 02, 2020 Rating: 5

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