Inflammation and effects of acute inflammation






Inflammation is a defense mechanism in the body.Inflammation is a defense mechanism in the body. The immune system recognizes damaged cells, irritants, and pathogens, and it begins the healing proces
When something harmful or irritating affects a part of our body, there is a biological response to try to remove it. The signs and symptoms of inflammation can be uncomfortable but are a show that the body is trying to heal itself.





Effects of acute inflammation:

Beneficial effects

 Dilution of toxins: The concentration of chemical and bacterial toxins at the site of inflammation is reduced by dilution in the exudate and its removal from the site by the flow of exudates from the venules through the tissue to the lymphatics.

Protective antibodies: Exudation results in the presence of plasma proteins including antibodies at the site of inflammation. Thus, antibodies directed against the causative organisms will react and promote microbial destruction by phagocytosis or complement-mediated cell lysis.

Fibrin formation: This prevents bacterial spread and enhances phagocytosis byleukocytes.¾ Plasma mediator systems provisions: The complement, coagulation, fibrinolytic, and kinin systems are provided to the area of injury by the process of inflammation.

Cell nutrition: The flow of inflammatory exudates brings with it glucose, oxygen and other nutrients to meet the metabolic requirements of the greatly increased numberof cells. It also removes their solute waste products via lymphatic channels.

Promotion of immunity: Micro-organisms and their toxins are carried by the exudates, either free or in phagocytes, along the lymphatics to local lymph nodes where they stimulate an immune response with the generation of antibodies and cellular immune mechanisms of defense.

Harmful effects

Tissue destruction: Inflammation may result in tissue necrosis and the tissuenecrosis may, in turn, incite inflammation.

Swelling: The swelling caused by inflammation may have serious mechanical effects at certain locations. Examples include acute epiglottitis with interference in breathing; acute meningitis and encephalitis with effects of increased intracranial pressure.

Inappropriate response: The inflammatory seen in hypersensitivity reactions is inappropriate (i.e. exaggerated).





Acute inflammation may end up in:

Resolution: That is complete restitution of normal structure and function of the tissue,eg. Lobar pneumonia.

Healing by fibrosis (scar formation).

Abscess formation {Surgical law states -Thou shall (you should) drain all abscesses.} However, if it is left untouched, it may result in
- Sinus formation - when an abscess cavity makes contact with only one epithelial lining.
- Fistula formation: when an abscess tract connects two epithelial surface.Or very rarely to septicemia or Pyemia with subsequent metastatic abscess in heart, kidney and  brain
Inflammation and effects of acute inflammation Inflammation and effects of acute inflammation Reviewed by gafacom on September 12, 2019 Rating: 5

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