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Amoebiasis: A parasitic infection

Amoebiasis is a parasitic infection of the intestine caused ny the protozoan Entamoeba histolytica, or E.histolytica. E.histolytica is a single celled protozoan that usually enters the human body when a person ingests cysts through food or water. It can also enter the body through direct contact with fecal matter.

Amoebiasis is a parasitic infection of the intestine caused ny the protozoan Entamoeba histolytica
The cysts are relatively inactive form of the parasite that can live for several months in the soil or environment where they were deposited in feces. The microscopic cysts are present in soil, fertilizer, or water that has been contaminated with infected feces.

Symptoms of the disease

  • Loose stools and stomach cramping
  • Abdominal pain
  • Diarrhea or blood diarrhea
Inflammation of the colon may be seen to complicated disease, death or perforation may result to peritonitis. people affected may develop anemia due to loss of blood


For tissue disease: metronidazole, tinidazole, nitazoxanide, dehydroemetine, chloroquine,secnidazole, ornidazole
Luminal infection: diloxanide furoate, iodoquinoline, tetracycline, erythromycin, paromomycin 

Contraindications of amoebic drugs

Metronidazole and tinidazole are contraindicated to people who have taken alcohol
To reduce the development of drug resistant bacteria and maintain the effectiveness of flagyl (metronidazole) and other antibacterial drugs. Metronidazole should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Metronidazole has shown to be carnigenic in mice and rats. unnecessary use of drug should be avoided

Side effects and adverse effects of amoebic drugs 
  • Stomach pain, diarrhea
  • dizziness, loss of balance
  • vaginal itching and discharge
  • dry mouth or unpleasant metallic taste
  • cough, sneezing, runny or stuffy nose
  • swollen or sore tongue
  • anorexia,constipation
  • headache
uncomfortable side effects
  • fevers
  • pain with urination mouth sores
  • tingling or pickling sensations that may become permanent
  • brain disease
  • seizures
serious side effects but unlikely to occur
  • unsteadness
  • seizures
  • mood changes
  • numbness


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