Dydrogesterone | Duphastone | Orally active progesterone

This medicine is also known as Duphaston which is the registered trademark. 
Pharmacotherapeutic group: Genitourinary system and sex hormones

Dydrogesterone is an orally active progestogen which produces a complete secretory endometrium in an oestrogen primed uterus thereby providing protection for oestrogen induced increased risk for endometrial hyperplasia and / or carcinogenesis. It is indicated in all cases of endogenous progesterone deficiency.
Pharmacotherapeutic group: Genitourinary system and sex hormones


Hormonal replacement therapy
Is indicated to counteract the effects of unopposed oestrogen on the endometrium 
(inner lining of the uterus) in hormonal replacement therapy for women with disorders 
due to naturally or surgically induced menopause with an intact uterus.

Progesterone deficiencies such as

Treatment of dysmenorrhea (painful menstruation)
Treatment of endometriosis (growth of uterine tissues outside the uterus with associated symptoms)
Treatment of secondary amenorrhea (cessation of menstruation)
Treatment of irregular cycles
Treatment of dysfunctional uterine bleeding
Treatment of premenstrual syndrome
Treatment of threatened and habitual abortion, associated with proven progesterone deficiency
Treatment of infertility due to luteal (ovarian yellow body) insufficiency
Dosage and administration

Always take the medicine as prescribed. If you have any question ask your doctor or pharmacist.
If you forget to take your tablet(s), do not take a double dose to compensate for it.
If you require further information, please ask your doctor or pharmacist for advice

For hormonal replacement therapy

In combination with continuous oestrogen therapy, take one tablet daily for 14 consecutive days of 28 day cycle.
In combination with cyclical oestrogen therapy take one tablet daily during the last 12 to 14 days of oestrogen therapy
For doctor: if endometrial biopsies or ultrasound reveal inadequate progestronal response, 20 mg dydrogesterone should be prescribed

Posology for specific indications

Take one tablet twice daily from day 5 to day 25 of the cycle
Endometriosis: Take one tablet two or three times daily from day 5 to day 25 of the cycle or continuously as prescribed by the doctor.
Dysfunctional bleeding (to stop bleeding): Take one tablet twice daily for five to seven days
Dysfunctional bleeding (to prevent bleeding): Take one tablet twice daily for from day 11 to day 25 of the cycle
Amenorrhea: Your doctor should prescribe an oestrogen along with dydrogesterone. Then take the oestrogen once daily from day 1 to day 25 of the cycle or continuously (as prescribed by the doctor)
Irregular cycle: Take one tablet twice daily from day 11 to day 25 of the cycle
Premenstrual syndrome: Take one tablet twice from day 11 to day 25 of the cycle
Threatened abortion: Take four tablets at once, then one tablet every eight hours until symptoms abate
Habitual abortion: Take one tablet twice daily until the twentieth week of pregnancy.
Infertility due to luteal insufficiency: Take one tablet daily from 14 to 25 of the cycle. Continue the treatment for at least six consecutive cycles.


      Hypersensitive (allergic) to the active substance or to any of the excipients
      Have a known or suspected progestogen dependent neoplasm
      Have undiagnosed vaginal bleeding
      Are using this medicine to prevent hyperplasia, specifically if you are also taking oestrogens


Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines including medicines obtained without prescription.

Effect on ability to drive and use machines

Dydrogesterone has no or negligible influence on the ability to dive and use machines

Undesirable effects

      Abnormal hepatic function
      Allergic dermatitis
      Breast pain
      Depressed mood
      Breast swelling

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